“You may choose to look the other way, but you can never say again that you did not know.”

— William Wilberforce

Infections
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Fever is Not an Enemy

woman with a feverStory Highlights
  • Treating fever with Tylenol (acetaminophen) is counterproductive for many reasons, not least of which is the drug’s toxic effects on the liver.
  • Fever is one of the body’s oldest and most reliable tools for fighting disease or infection, creating an inhospitable environment for pathogens and activating the immune system.
  • Reducing a fever with acetaminophen has a number of negative effects, including reduction of glutathione levels important to numerous cellular functions.

One of the most common recommendations for fever is to alleviate it by giving Tylenol (acetaminophen). Although may sometimes be unpleasant to experience fever or to care for a feverish child, it is important to understand that fever itself is a symptom of the body’s immune system fighting an infection or illness.

Defined as “a temperature of 100.4°F (38°C) and higher when taken rectally,” fever generally reflects a normal immune system response and indicates that the body is mounting an inflammatory assault against the “invaders.”1

Several benefits of fever have been identified: A higher than normal body temperature provides a less hospitable environment for many temperature-sensitive pathogenic viruses and bacteria. The elevated temperature also stimulates both the innate and the adaptive branches of the immune system, improving the recruitment and activity of many types of immune system cells and serving as a type of “systemic alert system” in the presence of infection or disease.2

Mechanically reducing fever via medication has been associated with a five percent increase in incidence of death from influenza, and also has been found to have a negative effect on outcome for hospitalized patients in intensive care.3

Acetaminophen is Not Without Risk

While there are widespread reminders that aspirin must not be given to children because of its rare association with Reye syndrome, the dangers of acetaminophen are downplayed, and it remains the treatment most often recommended for treatment of fever in children. Yet, the truth is that this common over-the-counter medication has a number of characteristics that can make it a dangerous drug.

Acetaminophen is a pervasive drug that is present in numerous combination medications in addition to single-agent pain and fever-reducing like Tylenol. It is estimated that some 52 million people in the United States use an acetaminophen-containing medication every week, close to a quarter of the population.4

As acetaminophen is considered safe for use during pregnancy and for small children, it is easy to understand why label warnings about dose limitations are taken lightly. However, habitually taking even a small amount over the recommended maximum daily dosage of 4,000 mg may lead to serious liver damage over time (one extra strength Tylenol pill contains 500 mg).

It has been reported that intentional or accidental overdose of acetaminophen is responsible for as much as 50 per cent of overdose-induced acute liver failure in this country, and for 20 percent of liver transplants.5 The Federal Drug Administration (FDA) has also issued warnings that acetaminophen may rarely cause one of three different types of serious skin infections that can lead to disfigurement or even death.6

Cellular Glutathione is Depleted by Acetaminophen

One of the factors that make acetaminophen so dangerous, especially for children, is its impact on the body’s glutathione levels.

Glutathione is a small but powerful protein comprising three different amino acids and has been dubbed “the body’s own master antioxidant.” Glutathione plays an important role in more cellular functions than can be covered in this article but includes such critical activities as cell growth, division, and repair; enzyme activation and function; transport of amino acids and other cellular substances; metabolism of toxins; and protein synthesis. It is at the core of healthy immune system response, both enhancing cellular activity and protecting the immune system cells.7

Studies have shown a dose- and time-sensitive association between acetaminophen use and depletion of intracellular glutathione levels. Depleted levels of glutathione in turn decrease the cell’s ability to process toxic free radicals.8

Combination of Acetaminophen and Vaccination is Dangerous

Giving Tylenol routinely to children to prevent fever following vaccination may be particularly dangerous as it reduces the body’s ability to process the injected toxins. It also has been recognized since 2009 that acetaminophen reduces the immune system’s ability to mount a strong response to the vaccine.9 10

Increasing evidence supports the “let it ride” theory about fever: Except under specific circumstances, as when a fever is dangerously high, the body has the ability to fight infection with fever, one of its oldest and most enduring tools.11


References:

1 Health Library. Fever in Children. Johns Hopkins Medicine. Oct. 17, 2016.
2 Evans S, et al. Fever and the Thermal Regulation of Immunity: The Immune System Feels the Heat. Nat Rev Immunol June 2015.
3 Ibid.
4 Whiteman H. Acetaminophen: Is It as Safe as We Think? Medical News Today July 27, 2016.
5 
Yoon E, et al. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update.  J Clin Transl Hepatol June 28, 2016.
6 
U.S. Food and Drug Administration. FDA Warns of Rare Acetaminophen Risk. FDA.gov Mar. 20, 2017.
7 Immune Health Science. 
What Glutathione (GSH) Is and How It Affects Your Immune Health. ImmuneHealthScience.com June 7, 2017.
8 
Yoon E, et al. Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update.  J Clin Transl Hepatol June 28, 2016.
9 Associated Press. Study: Avoid Tylenol After Vaccinations. CBS News Oct. 16, 2009.
10 
Paddock C. Routine Use Of Paracetamol (Acetaminophen) After Vaccination Not Recommended For Infants, Study. Medical News Today Oct. 19, 2009.
11 
Ray JJ, Schulman CI. Fever: Suppress It or Let It Ride? J Thorac Dis December 2015.

4 Responses to Fever is Not an Enemy

  1. Fergus Reilly Reply

    June 30, 2017 at 7:27 pm

    Except when we are the infection and the planet is the patient – except that is called global warming.

  2. Francine Reply

    June 27, 2017 at 10:27 pm

    I agree fever is good and tylenol is bad. With that said, there are herbs called febrifuge. There are also homeopathics as well. Belladona is one that apparently works well in small children and infants. Cool bandages may also be good. High fever might go up rapidly before you get a chance to test the temperature to verify if it’s acceptable.
    High fever from typhoid fever caused my friend’s hair to fall out, and his fellow student’s teeth to fall out. It can also mess up the brain.

  3. Mona Lisa McCormick Reply

    June 27, 2017 at 11:18 am

    What do you think about this article??

    HHS Public Access
    Author manuscript
    Autism Open Access. Author manuscript; available in PMC 2016 September 30.
    Published in final edited form as:
    Autism Open Access. 2016 April ; 6(2): . doi:10.4172/2165-7890.1000170.

    Acetaminophen Use for Fever in Children Associated with Autism Spectrum Disorder
    Stephen T Schultz* and Georgianna G Gould
    Department of Physiology, School of Medicine, University of Texas Health Science Center San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA

    Abstract
    Autism Spectrum Disorder (ASD) is characterized by persistent deficits in social communication and restrictive behavior, interests, and activities. Our previous case-control study showed that use of acetaminophen at age 12–18 months is associated with increased likelihood for ASD (OR 8.37, 95% CI 2.08–33.7). In this study, we again show that acetaminophen use is associated with ASD (p = 0.013). Because these children are older than in our first study, the association is reversed; fewer children with ASD vs. non-ASD children use acetaminophen as a “first choice” compared to “never use” (OR 0.165, 95% CI 0.045, 0.599). We found significantly more children with ASD vs. non- ASD children change to the use of ibuprofen when acetaminophen is not effective at reducing fever (p = 0.033) and theorize this change in use is due to endocannabinoid system dysfunction. We also found that children with ASD vs. non-ASD children are significantly more likely to show an increase in sociability when they have a fever (p = 0.037) and theorize that this increase is due to anandamide activation of the endocannabinoid system in ASD children with low endocannabinoid tone from early acetaminophen use. In light of this we recommend that acetaminophen use be reviewed for safety in children.

    Keywords
    Autism; Autism spectrum disorder; Acetaminophen; Anandamide; Endocannabinoid; Cannabinoid; Fever; Medication

  4. Mark Reply

    June 27, 2017 at 8:52 am

    A fever triggers the immune system, especially white blood cells, to produce excessive amounts of enzymes to destroy “not-self” pathogens. Enzymes not only work harder they are used up faster during a fever. Supplying proteolytic enzymes during a fever ensures rapid passing of the fever because the enzymes kill all pathogens. Suppressing a fever prolongs the period of infection also slowing recovery.

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