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Study: Febrile Seizure Risk Higher When Childhood Vaccines Given Simultaneously

six syringes in vaccine bottle

In practice, most childhood vaccines are administered simultaneously with other vaccines.

The link between febrile seizures—seizures associated with a fever in a child—and vaccines may be old news, but a new study published in the June 2016 issue of the journal Pediatrics confirms what parents have suspected for a long time:  the risk of seizures is higher for children when doctors give them many vaccines at the same time.

Febrile Seizures Historically a Recognized Risk of Flu Vaccine

Public health officials at the U.S. Centers for Disease Control and Prevention (CDC) have long recognized that there is a higher risk for febrile seizures when doctors administer flu shots to young children, particularly if influenza vaccine is given along with the pneumococcal conjugate (PCV) 13-valent vaccine or diphtheria, tetanus, pertussis (DTaP)-containing vaccines.1

The CDC cites a study from the March 2012 issue of Vaccine, which pulled data from the Vaccine Safety Datalink, a database monitoring vaccinated children in nine U.S. health systems. Near real-time monitoring included more than 200,000 Australian children aged between six months and five years who had febrile seizures within one day of the final dose of trivalent inactivated influenza vaccine during the 2010-2011 influenza season. Researchers found that the risk of febrile seizures was nearly six times higher immediately following simultaneous administration of flu vaccine and the 13-valent pneumococcal vaccine.2

Alerted by the greater febrile seizure risk, the CDC and the U.S. Food and Drug Administration (FDA) conducted heightened safety surveillance of possible febrile seizure in all trivalent influenza vaccine products during the 2010-2011 influenza season using the Vaccine Adverse Event Reporting System (VAERS). This was also the year the 13-valent PCV was introduced in the United States and replaced the older 7-valent PCV given to infants and children since 2001. By December 10, the agencies confirmed 43 reports of febrile seizure in children following administration of trivalent influenza vaccine.3

Despite the CDC’s acknowledgement of the risk, the agency maintains that the benefits outweigh the risks and no changes should be made to the federally recommended childhood vaccination schedule.4

Newest Study Quantifies Febrile Seizure Risk

The new data presented in the Pediatrics study help quantify how often children may experience febrile seizures after receiving the trivalent flu vaccine when it is given at the same time with either PCV or a DTaP-containing vaccine.

Using the Vaccine Safety Datalink, researchers studied children aged six to 23 months who had a febrile seizure within zero to one days of at least one of the three vaccines between 2006 and 2011, which encompassed five flu seasons. In total, there were 333 febrile seizures confirmed following nearly two million vaccinations.

Multivariate modeling identified the potential interaction between the PCV, DTaP-containing and the trivalent flu vaccines. Only PCV was linked with an independent higher risk of febrile seizures.

In terms of concomitant administration, the relative risk was highest when all three vaccines were administered together. The researchers estimated that 30 out of 100,000 children will experience a febrile seizure following simultaneous administration of the PCV, flu and DTaP-containing vaccines.

Similar to the CDC statement, the study authors noted “the risk of febrile seizure must be weighed against the benefits of timely vaccination as recommended.”5

In a separate accompanying editorial, American Academy of Pediatrics Committee on Infectious Disease members wrote that the rate of 30 seizures per 100,000 vaccinated children means that for the average pediatrician who may care for 1,000 patients younger than five years, he/she could expect to see one child who experiences a febrile seizure due to concomitant vaccine administration every five to 10 years.6

Influenza Vaccine Not the Only Culprit

The Pediatrics study did not identify regression models with more than three-way interaction terms, but the authors noted that they “cannot rule out the possibility that vaccine combinations other than those described above might also be associated with an increased risk of febrile seizure.”7

Additional studies have linked the febrile seizure risk to other vaccines recommended for children, like the combination diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus flu type B (DTaP-IPV-Hib)8 and measles-mumps-rubella-varicella (MMRV), a fact that 29% of pediatricians and 74% of family physicians do not know.9

In practice, most childhood vaccines are administered simultaneously with each other. At two months, federal health officials recommended infants receive eight vaccinations at once: diphtheria, tetanus and pertussis (DTaP), inactivation polio (IPV), haemophilus influenza B (Hib), rotavirus, hepatitis B and PCV. At six months old, infants are given the first influenza shot and can receive eight or nine vaccines at once.10


References:

1 Centers for Disease Control and Prevention. Febrile Seizures Following Childhood Vaccinations, Including Influenza Vaccination. CDC.gov Nov. 4, 2015 (updated).  
2 Tse A, Tseng HF, Greene SK, et al. Signal identification and evaluation for risk of febrile seizures in children following trivalent inactivated influenza vaccine in the Vaccine Safety Datalink Project, 2010-2011. Vaccine 2012;30:2024-31

3
Leroy Z, Broder K, Menschik D, et al. Febrile seizures after 2010-2011 influenza vaccine in young children, United States: A vaccine safety signal from the vaccine adverse event reporting system. Vaccine 2012;30:2020-23.
4 
See Footnote 1.
5 
Fuffy J, Weintraub E, Hambidge SJ, et al. Febrile Seizure Risk After Vaccination in Children 6 to 23 Months. Pediatrics 2016;138.
6 
Sawyer MH, Simon G, Byington C. Vaccines and Febrile Seizures: Quantifying the Risk. Pediatrics 2016;138.
7 
See Footnote 5.
8 
Sun Y, Christensen J, Hviid A, et al. Risk of Febrile Seizures and Epilepsy After Vaccination With Diphtheria, Tetanus, Acellular Pertussis, Inactivated Poliovirus and Haemophilus Influenzae Type b. JAMA 2012;307:823-31.
9 
O’Leary ST, Suh CA, Marin M. (MMRV) vaccine: What do primary care physicians think? Vaccine 2012. 30:6731-3.
10 
National Vaccine Information Center. Vaccination Dose Schedule. NVIC.org July 3, 2016 (accessed).

13 Responses to Study: Febrile Seizure Risk Higher When Childhood Vaccines Given Simultaneously

  1. Mack Lare Reply

    August 31, 2016 at 10:20 am

    “The basic message is, while there is an increase compared to giving them on separate days, the absolute amount of that risk is so, so very small that for the average person, it won’t really affect their chances of having a febrile seizure,” lead study author Jonathan Duffy tells Shots. Febrile seizures occur most typically in children between 1 and 2 years old — the same ages when children receive a number of vaccines. Sometimes other seizures may follow if the child has a disorder such as epilepsy, but no evidence has suggested that a febrile seizure can cause seizure disorders.

  2. Susan Reply

    August 8, 2016 at 3:43 pm

    A whole society tricked into thinking injecting toxins into our bodies somehow equates with health. I get how it happened (people trust doctors, doctors are trained by Pharma-controlled institutions, and media is controlled by Pharma, as well.) But really. Just stop and think, and protect your child and yourself.

  3. Mark Reply

    August 1, 2016 at 3:00 pm

    If anyone wanted to see how insane this world has become, all one has to do is look at the vaccination schedule for an infant. 25 vaccines given within the first seven months to an infant whose immune system is not anywhere nearly developed. It is not “scientifically” nor medically justifiable. It is unethical. It is not in the best interests of the infant or family. It has never been proven to protect or prevent disease. At best it is a way to create a lifetime patient for the medical business/industry. At worst it is attempted murder and/or child abuse. Anyone who says differently reveals their own ignorance on the subject and dependence on the news media (owned by the same families of the pharmaceutical companies) or is a paid shill/troll of the vaccine manufacturing industry.
    The level of ignorance in this country has gone far beyond anything prior to the history of the world.

  4. Alexandra Hayes Reply

    July 29, 2016 at 3:04 pm

    Thank you for sharing this study. I look forward to reading it in Pediatrics. I need clarification on the last paragraph though- it is stated that a two month old could get 8 vaccines? DTaP (diphtheria, tetanus and pertussis) only come as one vaccine. They aren’t available separately. So I am confused about how many are stated? Thanks for your time.

    • Karen Peterson Reply

      August 1, 2016 at 3:33 pm

      The DTaP Alexandra is 3 vaccines in one. It is only one shot though.

  5. Darryl Lynn Reply

    July 29, 2016 at 2:23 pm

    Let’s discuss (Polysorbate 80) which is not only found in numerous vaccines, but also in Children’s Tylenol. It acts as a catalyst to easily carry “Toxic Vaccine Ingredients” across the (Blood Brain Barrier). Below is the first paragraph about (Polysorbate 80).
    Clinical studies have shown darbepoetin alfa (polysorbate 80) to increase the risk of serious side effects (eg, blood clots, stroke, heart attack, heart failure) and death in some cases. It has also been shown to shorten overall survival and/or increase the risk of tumor growth or recurrence in patients with certain types of cancer. Talk with your doctor about the risks and benefits of using darbepoetin alfa (polysorbate 80). Do not use more than the recommended dose without checking with your doctor.

    https://www.drugs.com/cdi/darbepoetin-alfa-polysorbate-80.html

    • Jane Reply

      August 13, 2016 at 4:31 pm

      Polysorbate 80 is in parentheses, not because it is another name for the drug darbepoetin alfa, but because it is an adjuvant in that drug

  6. Donna Reply

    July 29, 2016 at 12:21 pm

    I don’t think vaccines of any kind of any amount and especially in children and babies or any other person are good – period. Earlier this week, we went out to the Amish community and we saw 4 young children – all under the age of 10 – all from the same family. What I saw was brilliance, clearness, healthy, alert, far different than what I see in the public schools in town with children of comparable ages and older. I don’t believe they vaccinate and we are not vaccinating our granddaughter or grandson – The same clarity and brilliance I see in our granddaughter’s behaviour and appearance. I don’t care what kind of studies are done – vaccines do more harm than good – unless by good it is a matter of making money for someone. – and in the case of vaccines too much money for an already very powerful cartel.

    • Jane Reply

      August 13, 2016 at 4:28 pm

      Actually, most of the Amish DO vaccinate

  7. Jillian Olson Reply

    July 29, 2016 at 12:06 pm

    My child had a seizure (12 hours after a fever, but not during, as far as we know…). It was a one time incident. We are 100% non-vacc & we take great care of our spines. If anyone was interested in our case / statistics we are willing to share!

    Jillian Olson
    Neenah, WI
    Jillian.a.olson@gmail.com

  8. MAJ. jesse carnes Reply

    July 29, 2016 at 10:45 am

    The multiple vaccine SCENARIO is called a “Cocktail” injection: notably toxic and quite deleterious to Microglia cells’ mitochrondria function, due to the VAST amounts of Aluminium hydroxide, Thimerosal, Steal viruses, pests virus, broken DNA fragments, etc etc

    Frighteningly dangerous.

    • MAJ. jesse carnes Reply

      July 29, 2016 at 10:47 am

      typographical CORRECTION :

      The multiple vaccine SCENARIO is called a “Cocktail” injection: notably toxic and quite deleterious to Microglia cells’ mitochrondria function, due to the VAST amounts of Aluminium hydroxide, Thimerosal, Stealth-viruses, peste viruses, broken DNA fragments, MSG, etc etc

      Monstrously dangerous.

      • Jane Reply

        August 13, 2016 at 4:27 pm

        So trace amounts = “vast” amounts now?

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